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SYNTHESIS OF 2,3-DIHYDROQUINAZOLIN-4(1H)-ONES USING BRONSTED ACIDIC IONIC LIQUID
Pages : [123] - [135]
Received : December 25, 2013; Revised February 12, 2014
Communicated by : Professor Ana Rosa Silva
Abstract
2,3-Dihydroquinazolin-4(1H)-ones were efficiently synthesized via one-pot, three-component reaction of isatoic anhydride, primary amines or ammonium acetate, and different aromatic aldehydes in the presence of 3-methyl-1-sulphonic acid imidazolium hydrogen sulphate as an efficient Brønsted acidic ionic liquid in aqueous media. The catalyst could be recovered and reused for at least four cycles without significant loss of activity.
Keywords
2,3-dihydroquinazolin-4(1H)-one, three-component reaction, ionic liquid, isatoic anhydride, aqueous media.